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Discovery of small molecule degraders for modulating cell cycle
Frontiers of Medicine Pages 823-854 doi: 10.1007/s11684-023-1027-5
Keywords: PROTAC molecular glue degrader cell cycle CDK cyclin
Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 128-135 doi: 10.1007/s11705-021-2080-8
Keywords: fluorescence probes iron screening library
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 15-26 doi: 10.1007/s11705-017-1629-z
Keywords: biosensor small molecule product transcription factor riboswitch high-throughput screening
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 449-461 doi: 10.1007/s11684-017-0589-5
Keywords: emerging and re-emerging viruses small-molecule inhibitor coronavirus Ebola virus Zika virus life cycle
Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 34-63 doi: 10.1007/s11705-021-2050-1
Keywords: hydrogen sulfide fluorescent probe reducibility nucleophilicity copper sulfide precipitate hydrogen polysulfides
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Frontiers of Medicine doi: 10.1007/s11684-023-1037-3
Keywords: COVID-19 antiviral drugs mindeudesivir
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 275-289 doi: 10.1007/s11684-022-0945-y
Keywords: epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin
Vaibhav Mundra, Ram I. Mahato
Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4, Pages 387-404 doi: 10.1007/s11705-014-1457-3
Keywords: nanocarrier cellular uptake endosomal release nucleic acid drug
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 4-33 doi: 10.1007/s11705-021-2041-2
Keywords: bioactive molecules fluorescent probes in living cells and in vivo review
Qi Chen1 , Cen Zhang1 , Lingwei Xue1,2 , Zhi-Guo Zhang1
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10, Pages 1526-1529 doi: 10.1007/s11705-022-2161-3
Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu
Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 60-67 doi: 10.1007/s11684-019-0694-8
Keywords: BPTF small molecule epigenetics non-small-cell lung cancer
Hui Xiong, Ai-Hua Zhang, Ya-Jing Guo, Xiao-Hang Zhou, Hui Sun, Le Yang, Heng Fang, Guang-Li Yan, Xi-Jun Wang
Engineering 2021, Volume 7, Issue 9, Pages 1293-1305 doi: 10.1016/j.eng.2020.12.016
A herbal prescription in traditional Chinese medicine (TCM) has great complexity, with multiple components and multiple targets, making it extremely challenging to determine its bioactive compounds. Yinchenhao Tang (YCHT) has been extensively used for the treatment of jaundice disease. Although many studies have examined the efficacy and active ingredients of YCHT, there is still a lack of an in-depth systematic analysis of its effective components, mechanisms, and potential targets—especially one based on clinical patients. This study established an innovative strategy for discovering the potential targets and active compounds of YCHT based on an integrated clinical and animal experiment platform. The serum metabolic profiles and constituents of YCHT in vivo were determined by ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC-Q-ToF-MS)-based metabolomics combined with a serum pharmacochemistry method. Moreover, a compound–target–pathway network was constructed and analyzed by network pharmacology and ingenuity pathway analysis (IPA). We found that eight active components could modulate five key targets. These key targets were further verified by enzyme-linked immunosorbent assay (ELISA), which indicated that YCHT exerts therapeutic effects by targeting cholesterol 7a-hydroxylase (CYP7A1), multidrug-resistance-associated protein 2 (ABCC2), multidrug-resistance-associated protein 3 (ABCC3), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and farnesoid X receptor (FXR), and by regulating metabolic pathways including primary bile acid biosynthesis, porphyrin and chlorophyll metabolism, and biliary secretion. Eight main effective compounds were discovered and correlated with the key targets and pathways. In this way, we demonstrate that this integrated strategy can be successfully applied for the effective discovery of the active compounds and therapeutic targets of an herbal prescription.
Keywords: Efficacy Bioactive compound Small molecule Targets Herbal medicine Metabolomics
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 9, Pages 1208-1220 doi: 10.1007/s11705-023-2304-1
Keywords: molecular synergy pseudocapacitive lignosulfonate flexible electronic devices asymmetric supercapacitor wide voltage windows
Xiaowei LUO, Yannick BENICHOU, Suyuan YU
Frontiers in Energy 2013, Volume 7, Issue 4, Pages 506-510 doi: 10.1007/s11708-013-0275-5
Keywords: aerosol particles collision frequency function coagulation
A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum
Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 108-111 doi: 10.1007/s11684-014-0344-0
Keywords: gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib
Title Author Date Type Operation
Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores
Journal Article
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
Journal Article
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Journal Article
Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide
Journal Article
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Journal Article
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal
Journal Article
Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic
Vaibhav Mundra, Ram I. Mahato
Journal Article
Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
Journal Article
Bright future of polymerizing small-molecule acceptors in realizing high performance all-polymer solar
Qi Chen1 , Cen Zhang1 , Lingwei Xue1,2 , Zhi-Guo Zhang1
Journal Article
Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell
Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu
Journal Article
A Clinical and Animal Experiment Integrated Platform for Small-Molecule Screening Reveals Potential Targets
Hui Xiong, Ai-Hua Zhang, Ya-Jing Guo, Xiao-Hang Zhou, Hui Sun, Le Yang, Heng Fang, Guang-Li Yan, Xi-Jun Wang
Journal Article
A pseudocapacitive molecule-induced strategy to construct flexible high-performance asymmetric supercapacitors
Journal Article
Calculation of collision frequency function for aerosol particles in free molecule regime in presence
Xiaowei LUO, Yannick BENICHOU, Suyuan YU
Journal Article